Chemistry of Phosphonium Ylides. Part 39: Facile Synthesis of Aziridine, Pyridine, Pyrolotriazole Chromenones and Azaphosphinin Chromenones as Antitumor Agents

Abstract

The reaction of 4‐azido‐2‐oxo‐2 H ‐chromene‐3‐carbaldehyde with the active nucleophilic phosphacumulenes yielded the corresponding phosphanylidene‐aziridines and chromeno‐pyrolo‐triazoles. On the other hand, the reaction of the allylic phosphonium ylide, hexaphenylcarbodiphosphorane with the azido compound, was also undertaken. In this case, the phosphanylidene‐chromeno‐triazinone was obtained. Further assessment of these new compounds against (breast: MCF‐7 and liver: HPEG2) human solid tumor cell lines is necessary.