Increased Levels of Calbindin-D in Serum and Urine from Patients Treated by Extracorporeal Shock Wave Lithotripsy

Abstract

No AccessJournal of Urology1 Jun 1993Increased Levels of Calbindin-D in Serum and Urine from Patients Treated by Extracorporeal Shock Wave Lithotripsy Soichiro Hasegawa, Kanefusa Kato, Munehisa Takashi, Yuanyuan Zhu, Koji Obata, Tsuneo Kinukawa, and Koji Miyake Soichiro HasegawaSoichiro Hasegawa More articles by this author , Kanefusa KatoKanefusa Kato More articles by this author , Munehisa TakashiMunehisa Takashi More articles by this author , Yuanyuan ZhuYuanyuan Zhu More articles by this author , Koji ObataKoji Obata More articles by this author , Tsuneo KinukawaTsuneo Kinukawa More articles by this author , and Koji MiyakeKoji Miyake More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36403-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Calbindin-D 28kDa. is a vitamin D-dependent calcium binding protein that is found mainly in the distal renal tubules and central nervous tissue in humans. Calbindin-D was measured in the serum and urine before, and immediately, 2hours or 24hours after extracorporeal shock wave lithotripsy (ESWL* Dornier Medical Systems, Inc., Marietta, Georgia. ) in 83 consecutive patients. ESWL was performed with the Siemens Lithostar device in 61 patients and with the Dornier MPL9000 lithotriptor in 22. The serum 28kDa. calbindin-D level was undetectable (less than 20pg./ml.) in many samples, whereas urinary 28kDa. calbindin-D could be detected in every sample. The serum 28kDa. calbindin-D level was usually elevated after ESWL and the concentration in patients treated with the MPL9000 device was greater than in those treated with the Lithostar instrument. Urinary 28kDa. calbindin-D levels were elevated significantly immediately and at 2hours after ESWL, and they decreased to the baseline level within 24hours after ESWL in the Lithostar group but remained consistently significantly elevated after ESWL in the MPL9000 group. This fact may be because the MPL9000 lithotriptor produces a stronger shock wave than does the Lithostar device during ESWL. These results suggest that 28kDa. calbindin-D is released from damaged distal renal tubule cells into the serum and urine during ESWL and that 28kDa. calbindin-D is a specific marker for renal damage by ESWL. To our knowledge this is the first clinical study using a sensitive enzyme immunoassay for human 28kDa. calbindin-D to estimate renal damage during ESWL. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 149Issue 6June 1993Page: 1414-1418 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.Keywordskidney calculiextracorporeal shockwave lithotripsycalcium-binding proteinshydronephrosiskidney tubulesMetricsAuthor Information Soichiro Hasegawa More articles by this author Kanefusa Kato More articles by this author Munehisa Takashi More articles by this author Yuanyuan Zhu More articles by this author Koji Obata More articles by this author Tsuneo Kinukawa More articles by this author Koji Miyake More articles by this author Expand All Advertisement PDF DownloadLoading ...