Molecular and cellular changes induced by the activation of CB2 cannabinoid receptors in trabecular meshwork cells.

Abstract

This study demonstrates that by acting through CB2 receptors, the CB2-selective cannabinoid agonist JWH015 modulates the TM cell actin's cytoskeleton and migration. This study also shows that JWH015 modulates the activities of Rac1-GTPase and cofilin, which are important signaling molecules for the cytoskeletal and migratory properties of TM cells.