PubMed · 1995 · 14 citations · 0 references
Life SciencesImmunologyInfectious DiseasesCellular ImmunologyHost-pathogen InteractionsInnate ImmunityCell-mediated ImmunityCellular Immune ResponsesHost Defense Against InfectionHost-parasite Immune InteractionsNatural Killer Cell BiologyNatural Killer Cell FunctionNatural Killer Cell Cytokine ResponsesNatural Killer Cell CytotoxicityNatural Killer Cell Inhibitory SignalingToxoplasmosis Pathogenesis
That strong cytolytic activity of natural killer (NK) cells is neither necessary nor sufficient for defense against acute Toxoplasma gondii infection is demonstrated. T. gondii-infected anti-interferon (IFN)-gamma-treated mice and IFN-gamma gene knockout mice died despite good induction of NK activity, while infected beige mice, deficient in NK cytolytic activity, survived.