Lactate dehydrogenase isoenzymes in normal bovine serum and during experimental liver and muscle damage.

Abstract

Summary Lactate dehydrogenase (LDH) isoenzymes were determined in normal bovine serum and at different time intervals in sera from cattle with experimental liver and muscle damage. The fast-moving isoenzyme LDH1, increased in two phases during liver necrosis. The first phase appeared to be related to the liver damage, while a further increase was likely to be due to a general intoxication. LDH1 also increased after a period of 7 to 9 days’ starvation, possibly due to changes in the liver. The slow-moving isoenzyme LDH5 appeared to be largely muscle specific and the rise of its activity in serum appeared to bear some relationship to the extent ofthe muscle damage.