Characterization of platelet activation and thrombin generation accompanying percutaneous transluminal coronary angioplasty.

Abstract

We have shown that coronary sinus samples can be obtained under conditions permitting assessment of ongoing thrombosis in patients undergoing PTCA. Samples can be obtained without introduction of artifactual elevations of FPA or BTG, facilitating assessment of the efficacy of novel antithrombotic regimens in preventing thrombogenesis otherwise seen in an important minority of patients undergoing coronary interventions.