Antitumor Immunity in the Shope Papilloma-Carcinonia Complex of Rabbits. II. Suppression of a Transplanted Carcinoma, Vx7, by Homologous Papilloma Vaccine<xref ref-type="fn" rid="fn1">2</xref>

Abstract

Transfer of the Vx7 tumor, a carcinoma derived many years ago from a virus-induced rabbit papilloma, was readily accomplished to approximately 100 percent of previously untreated rabbits. Successful transplantation of this tumor was reduced to a rate of approximately 50 percent when rabbits were inoculated with a vaccine containing fresh homologous papilloma tissue 2 or 4 weeks before transfer of the Vx7 tumor. A small area of scarified skin was inoculated with virus at the time of vaccination. Papillomas appeared and in some animals regressed. Suppression of the growth of Vx7 tumor showed no correlation with regression or persistence of the cutaneous papilloma.