Publication | Closed Access
Direct evaluation of class-specific anti-DNA antibodies by an immunoenzymatic technique.
11
Citations
0
References
1980
Year
ImmunohematologyImmunologyGenetic EpidemiologyPathologyDna AnalysisImmunotherapyFarr TestSerologic TestingNative DnaImmunochemistryAntibody EngineeringClass-specific Anti-dna AntibodiesAllergyAutoimmune DiseaseSystemic Lupus Erythematosus TreatmentSystemic LupusLupus NephritisAutoimmunityAntibody ScreeningMolecular Diagnostic TechniquesLupusGenetic EngineeringMedicine
Antibodies against native DNA have been evaluated by an immuno-enzymo assay (ELISA) using glucose oxidase labelled Ig class-specific antibodies. Results of the ELISA test were significantly correlated with those of the Farr test performed with native DNA as well as with the degree of clinical activity. ELISA is proposed as a simple method for the direct evaluation of class-specific anti-native DNA antibodies in systemic lupus and related diseases.