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Effect of glutathione-modulating compounds on platinum compounds-induced cytotoxicity in human glioma cell lines.
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2000
Year
Neuro-oncologyGlutathione-modulating CompoundsPlatinum Compounds-induced CytotoxicityBiochemistryMedicinePlatinum CompoundsCell LinesGlioma Cell LinesCellular PharmacologyToxicologyAnti-cancer AgentCancer TreatmentPharmacologyGliomaTumor BiologyToxicological MechanismOxidative Stress
The relation between the effect of glutathione(GSH)-modulating compounds and platinum compounds (Cisplatin, Nedaplatin)-induced cytotoxicity was investigated. Pretreatment of human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines with L-buthionine-[S,R]-sulfoximine, which decrease the intracellular GSH concentration, remarkably increased their sensitivity against platinum compounds, whereas pretreatment with N-acetyl-L-cysteine, which increase the intracellular GSH concentration, only marginally protected the cells from the cytotoxic effect of platinum compounds. The results suggest that platinum compounds-induced cytotoxicity can be modified by GSH-modulating compounds in glioblastoma and glioma cell lines.