PubMed · 1998 · 19 citations · 0 references
PharmacyPharmacokineticsPharmacologyClinical PharmacologyPediatric Clinical PharmacologyPediatric TherapeuticsBlood-brain Barrier PenetrationBlood-brain Barrier PharmacologyDrug DispositionPediatric PharmacokineticsPediatric PharmacologyBlood-brain Barrier PermeabilityBrain-to-plasma RatioCentral Nervous System Drug ExposureCerebrospinal Fluid DistributionContinuous Infusion PharmacologyDrug Distribution In ChildrenDrug Half-life In ChildrenPharmacokinetics At The Blood-brain Barrier
The pharmacokinetics of ifosfamide and some metabolites in children was investigated. The patients received various doses of ifosfamide, mostly by continuous infusion, over several days. The penetration of ifosfamide and its metabolites into the cerebrospinal fluid was also studied in four cases. Ifosfamide and 4-hydroxyifosfamide pass the blood-brain barrier, reaching cerebrospinal fluid concentrations that are almost as high as plasma concentrations.