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A pilot study of low-dose fludarabine in membranous nephropathy refractory to therapy.

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Citations

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References

1999

Year

Boumpas Dt, Tassiulas Io, TA Fleisher, Ellen M. Vaughan, Stephen C. Piscitelli, Yonggyun Kim, Frank Pucino, Balow Je, Austin Y. Ha
PubMed

Abstract

We conclude that low-dose fludarabine treatment in patients with membranous nephropathy is well tolerated and results in significant lymphopenia involving B more than T cells. In this pilot study improvement in proteinuria and filtration rate were observed. Additional studies are required to determine the optimal dose and clinical efficacy of fludarabine.