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Some Haemodynamic Effects of Compound AH 5158 Compared with Propranolol, Propranolol plus Hydrallazine, and Diazoxide: The Use of AH 5158 in the Treatment of Hypertension
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1974
Year
HypertensionIntravenous AdministrationCompound Ah 5158Cardiovascular PharmacologyPharmacotherapyBlood PressureAlpha-adrenergic PharmacologyMolecular PharmacologyRenal PharmacologyAnesthetic PharmacologyEndocrine HypertensionSodium HomeostasisAntihypertensive TherapyAh 5158Diuretic ResistancePharmacologyPotassium HomeostasisCardiovascular DiseasePhysiologyAnesthesiaMedicineHaemodynamic Effects
1. Intravenous administration of compound AH 5158, which possesses alpha- and beta-adrenergic receptor-blocking properties, produces haemodynamic effects similar to those seen from the combined effects of propranolol and hydrallazine. 2. Chronic oral administration has demonstrated that compound AH 5158 is an effective hypotensive agent capable of controlling the blood pressure in patients previously requiring large doses of drugs such as methyldopa. Some postural and exercise hypotension may be seen with larger doses.