A slow transient kinetic process of yeast hexokinase

Abstract

During a study of some kinetic properties of yeast hexokinase (EC 2.7.1.1) we have observed transient changes in reaction progress curves, i.e. transients, going from an initial high activity to a lower steadystate activity. From steady-state kinetics Kosow & Rose (1970) have suggested the possibility of negative co-operativity in yeast hexokinase (PI,),