c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis. - Concepedia

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c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis.

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2004

Year

S. A. Vaziri, Dale Grabowski, Masahiro Tabata, Katherine A. Holmes, Joseph Sterk, Nagio Takigawa, Ronald M. Bukowski, Mahrukh K. Ganapathi, Ram Ganapathi

Abstract

These data suggest that KN-62 co-treatment sensitizes doxorubicin-resistant cells to VP-16-induced apoptosis by enhancing caspase activity and reducing c-IAP1 expression.