Publication | Closed Access
Genital organs. Auto and homotransplantation in forty dogs.
32
Citations
0
References
1975
Year
The study performed uterine and ovarian auto‑ and homotransplantation on 40 bitches in four groups—control, omentopexy auto‑transplantation, vascular anastomosis auto‑transplantation, and twin‑dog homotransplantation—without immunosuppression, evaluating graft viability by X‑ray, cytology, gonadotropin response, and relaparotomy at 3 weeks and 3 months. Omentopexy auto‑transplantation failed, with all 12 grafts degenerating by 3 months; vascular anastomosis auto‑transplantation produced a successful pregnancy and three healthy puppies; homotransplantation survived briefly but was necrotic after 3 months.
Auto and homo transplantation of the uterus and ovaries was studied in 40 bitches divided into four groups. Group A served as a control. In group B the omentopexy technique of auto-transplantation was used. This method did not prove very rewarding and all 12 grafts were found to have degenerated and were non-functioning when relaparotomy was performed, 3 months after transplantation. In group C, auto transplantation with vascular anastomosis was performed in 12 dogs, yielding satisfactory results including one successful pregnancy and the delivery of 3 healthy puppies. In group D homotransplantation of the internal genital organs was performed in two sets of twin dogs. No immunosuppressive treatment was used. These grafts survived for a limited period as proved by the functional tests and X-ray examination but after 3 months were found to be necrotic and degenerated. Graft function and viability was established by: X-ray examination, cytology of vaginal smears, the effect of gonadotropins on the grafted ovaries and finally relaparotomy undertaken after 3 weeks and 3 months.