Decreased expression of the CFTR protein in remodeled human nasal epithelium from non-cystic fibrosis patients.

Abstract

These results suggest that the localization of CFTR in human nasal surface epithelium is related to the differentiation state of this epithelium. Abnormally low expression of the CFTR protein may not only be caused by CFTR gene mutations but can also be associated with airway surface epithelium dedifferentiation and remodeling.