Adrenocortical and medullary effects of glucagon

Abstract

An isolated, perfused adrenal gland preparation in the dog was used to study the direct effect of glucagon on adrenal secretion of hydrocortisone, epinephrine and norepinephrine. Glucagon was demonstrated to have a marked stimulatory effect on catecholamine secretion while having no effect on hydrocortisone secretion. The physiologic implications of these findings are discussed.