Chlordiazepoxide and Hostility in Anxious Outpatients

Abstract

Chlordiazepoxide proved significantly better than placebo in reducing hostile, irritable, and anxious symptomatology in 225 anxious neurotic outpatients. The findings reported here failed to confirm the increases in hostility believed to be induced by chlordiazepoxide observed by others. The authors see little justification for avoiding use of chlordiazepoxide by anxious outpatients with concomitant hostility and irritability.