Concepedia

Publication | Closed Access

Loss of heterozygosity, microsatellite instability and TP53 gene status in ovarian carcinomas.

19

Citations

0

References

2008

Year

Joanna Plisiecka-Hałasa, Agnieszka Dansonka‐Mieszkowska, Ewa Kraszewska, Anna Dańska-Bidzińska, Jolanta Kupryjańczyk
PubMed

Abstract

Our results suggest that LOH at the 17p D17S926 locus in ovarian cancer is an earlier molecular event than LOH at the TP53 locus. Inactivation of TP53 and RB1 genes may have a synergistic effect in ovarian tumorigenesis.