Icodextrin'S Effects on Peritoneal Transport

Abstract

Icodextrin has no effect on the permeability characteristics of the peritoneal membrane, but increases convective flow through the small-pore system. As a result, the peritoneal clearance of beta 2-microglobulin is higher than with glucose-based solutions. Icodextrin is especially indicated for long dwells and in patients with impaired ultrafiltration caused by a large peritoneal surface area, leading to high transport rates of low molecular weight solutes.