Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases. - Concepedia

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Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases.

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References

2002

Year

Weixin Wang, Stephen J. Waters, John R. MacDonald, Caleb C. Roth, Shujun Shentu, James W. Freeman, Daniel D. Von Hoff, Alexander R. Miller

Abstract

Our data demonstrated that JNK1 and Erk1/2 are activated by Irofulven treatment and that blockade of either MAPK subfamily decreases apoptosis by rendering Irofulven incapable of inducing caspase activation.