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Substituted phenylacetylguanidines: a new class of antihypertensive agents.
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1975
Year
Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceDerivative (Chemistry)Compound 19BiochemistryPharmacological StudyMedicineNatural SciencesStructure-activity RelationshipsNew ClassPharmacotherapyNew SeriesPharmacologyPharmaceutical ChemistryDrug Discovery
The synthesis of a new series of phenylacetylguanidines is described. Several of them exhibited high antihypertensive activity in the rat. The most potent member of the series is N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride [2,6-dichlorophenylacetylguanidine hydrochloride, compound 19], which is now in clinical study under the clinical code number BS 100-141. The structure-activity relationships in this class of compounds are discussed.