A Fetal Hemoglobin with Abnormal γ-Polypeptide Chains: Hemoglobin Warren

Abstract

Abstract The discovery of a variant of fetal hemoglobin in the cord blood of a Negro newborn is reported. The abnormal hemoglobin, designated as Hb-Warren, was studied by different analytic procedures, such as starch gel electrophoresis, anion exchange chromatography, ultraviolet spectral absorption, immunologic reactivity with various antisera, hybridization with canine hemoglobin and the determination of the total amino acid composition. It was concluded that Hb-Warren was composed of normal α-polypeptide chains and abnormal γ-polypeptide chains.