Positional Cloning of the Chediak-Higashi Syndrome Gene: Genetic Mapping of the beige locus on Mouse Chromosome 13

Abstract

These studies indicate that a genomic rearrangement affecting Nid or Estm9 does not underlie bg. The bg locus has been localized on mouse Chromosome 13 with sufficient precision to enable rapid cloning of the bg non-recombinant interval and eventual identification of the gene for Chediak-Higashi syndrome among sequences within the interval.