Hormone and Metabolic Research · 1978 · 24 citations · 0 references
Life SciencesEndocrinologyPhysiologyGestational DiabetesReproductive EndocrinologyReproductive PhysiologyDiabetes MellitusHormone SecretionPancreatic EndocrinologyPancreatic HormonesPregnancy EndocrinologyPregnancy PhysiologyGlucose Sensing MechanismsGlucose-stimulated Insulin SecretionIslet Cell PhysiologyPancreatic Islet BiologyPancreatic Islet FunctionPancreatic Islet PhysiologyPancreatic Islet SecretionResponsiveness
Estimations of the secretory sensitivities of islets from 19-day pregnant rats to stimuli such as glucose, mannose and fructose, were compared with those of non-pregnant rats, and it was concluded that the hypersecretion of insulin in vitro from islets in pregnancy was through development specifically of extra responsiveness to glucose or its metabolites. The sensitisation of the glucose detecting mechanism in these islets was then investigated in a number of different ways.