Effects of adrenergic agents on colonic motility.

Abstract

Sympathetic hyperactivity has been implicated as an etiologic factor in postoperative ileus. The effects of methoxamine (alpha-agonist) and isoproterenol (beta-agonist) on colon contractions and blood flow were studied in nine monkeys. Phentolamine (alpha-antagonist) and propranolol (beta-antagonist) were used to block the effects of the appropriate agonist. Methoxamine caused a dose-related inhibition of colon contractions and a decrease in inferior mesenteric artery (IMA) blood flow. Isoproterenol caused a dose-related inhibition of colon contractions and an increase in IMA blood flow. The contractile and blood flow effects of methoxamine were blocked by phentolamine and those of isoproterenol by propranolol. Mechanical reduction of IMA blood flow by an amount equivalent to that observed with the highest dose of methoxamine caused no change in contractions in the segment of colon supplied by the IMA. Both alpha- and beta-agonists inhibit colon contractions and have the expected effects on IMA blood flow. The contractile and blood flow responses of the agonists can be blocked by appropriate antagonists. The blood flow changes are not responsible for the contractile changes. These results indicate that sympathetic hyperactivity may play a role in postoperative ileus.