Journal of the American Veterinary Medical Association · 1988 · 28 citations · 0 references
MedicineNeurologyNeuroscienceNeuroanatomyNeuromuscular DisordersNeuropathologyMotor Neuron DiseasesNeurodegenerative DiseasesNeurodegenerative DisordersRodent NeurologyWildlife NeuropathologyAxonal SpheroidsCerebellar DysfunctionCerebellar Purkinje CellsNeurologic DeficitsNeuropathological LesionsPurkinje Cell DegenerationPurkinje FibersVeterinary Neuropathology
An 8-month-old Rottweiler pup was evaluated for neurologic disorder. Clinical signs included ataxia, hypermetria of all 4 limbs, intention tremors of the head, lack of a menace reflex bilaterally, and mild proprioceptive deficits. The pup was euthanatized because of the progressive nature of the disease. Histopathologic findings consisted of decreased numbers of Purkinje cells in the cerebellum and moderate numbers of axonal spheroids in the nucleus cuneatus. This latter finding confirmed the diagnosis of neuroaxonal dystrophy.