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Detection of lung metastases from osteosarcoma by scintigraphy using 99mTc-methylene diphosphonate.
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1981
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Lung MetastasesOncologic ImagingMedical ImagingCancer DetectionMedicineOsteosarcoma MetastasesPathology99Mtc-methylene Diphosphonate 99Mtc-mdpBronchial NeoplasmOncologyNuclear Medicine99Mtc-methylene DiphosphonateLung CancerCancer ResearchRadiologyHealth Sciences
The results of 99mTc-methylene diphosphonate 99mTc-MDP scintigraphy in 37 osteosarcoma patients were evaluated. In 11 of 12 patients with pulmonary metastases these were demonstrated by the scintigram. In 2 of these 11 patients the lung metastases could be shown earlier by scintigraphy than by X-ray tomography. Uptake of 99mTc-MDP appeared to be correlated with the formation of osteoid by the tumor. 99mTc-MDP scintigraphy demonstrated metastases not only in the lungs and the skeleton, but also in the lymph nodes and soft tissues. 99mTc-MDP whole-body scintigraphy should be used routinely for the early detection of osteosarcoma metastases.