Concepedia

Publication | Closed Access

Medullary thyroid carcinoma in multiple endocrine neoplasia types 2A and 2B.

96

Citations

0

References

1994

Year

O'Riordain Ds, Timothy O’Brien, Weaver Al, H Gharib, Hay Id, Grant Cs, van Heerden Ja
PubMed

Abstract

Intensive biochemical screening of MEN 2 kindreds for MTC can result in detection of early disease and a significant prospect of surgical cure. Genetic testing promises additional benefits through more reliable detection of preinvasive disease, allowing prophylactic thyroidectomy in infancy. In MEN 2B, MTC is considerably more aggressive than in MEN 2A. A policy of routine thyroidectomy in infants with MEN 2B, regardless of serum calcitonin levels, is justified.