Primidone as a treatment for cerebellar tremor in multiple sclerosis--two case reports.

Abstract

Kinetic (intentional) tremor, resulting from demyelination of cerebellar connections, is a common and disabling symptom in multiple sclerosis. Until recently, there was no effective treatment for this symptom, which markedly impairs the quality of life in patients with this disease. In this report, we describe two multiple sclerosis patients whose trem- or was significantly reduced by primidone