Stenting of Renal Artery Stenosis in Coronary Artery Disease (RAS-CAD) study: a prospective, randomized trial

Abstract

From April 2006 on, all consecutive patients undergoing nonemergent coronary angiography at a single institution are also to be evaluated for RAS by selective renal arteriography. Patients with RAS>50% and <or=80% are randomly assigned to undergo stenting angioplasty plus medical therapy (angioplasty group) or medical therapy alone (drug therapy group) and followed up for 5 years. All randomized patients receive antihypertensive, lipid-lowering or antiplatelet drugs according to current clinical guidelines. The estimated sample size needed to achieve a 80% power to detect as statistically significant a 4 g/m2 difference in left ventricular mass index progression (p<0.01, 2-tailed) between the 2 arms is 168 (84 in the revascularization arm and 84 in the medical management arm).