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ALA-Dehydratase Activation by Zinc
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1971
Year
Iron MetabolismRedox BiologyOxidative StressToxicologyClinical ChemistryBiological Inorganic ChemistryInhibitory ActivityBiochemistryMedicineInhibitory ActionAla-dehydratase ActivationPharmacologyBioactive MetalMetalloproteinPhysiologyMetal ToxicityMetabolismδ-Aminolaevulinic Acid DehydrataseRed Blood Cells
It has been known for some years that lead and some other metals such as mercury and silver have an inhibitory action on the activity of δ-aminolaevulinic acid dehydratase (ALAD) in red blood cells. Zinc in small concentrations has likewise an inhibitory effect on ALAD, while, in higher concentrations, this metal gives a significant increase in the activity of ALAD in red blood cells. This was shown in in vitro as well as in vivo studies.