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Determination of the enantiomerization barrier of oxazepam by dynamic micellar electrokinetic chromatography--comparison of experiment and simulation with ChromWin 99.
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2000
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Pharmaceutical SciencePlateau FormationOrganic ChemistryChemistryMedicinal ChemistryEnantiomerization BarrierSeparation ScienceGas ChromatographyBioanalysisAnalytical ChemistryLiquid ChromatographyChromatographyChiral SurfactantSurfactant SolutionBiochemistryChromatographic AnalysisPharmacologyChromwin 99Natural SciencesMedicinePharmacokineticsRate ConstantsDrug Analysis
The pH-dependent and temperature-controlled enantiomerization of oxazepam has been studied by dynamic micellar electrokinetic chromatography in an aqueous buffer system with sodium cholate as the chiral surfactant. Experimental interconversion profiles featuring plateau formation were simulated by the new program ChromWin 99. Peak form analysis yielded rate constants and kinetic activation parameters of the enantiomerization of oxazepam between 5 degrees C and 25 degrees C.