Polymorphism of CYP450 and cancer susceptibility.

Abstract

CYP450s form a superfamily involved in the metabolism of many endogenous and exogenous substrates. In this review, the substrates, probe drugs, genetic polymorphisms, and associated cancers of CYP1A1, CYP1A2, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 are summarized.