PubMed · 1976 · 12 citations · 0 references
Life SciencesHematologyImmunologyImmunopathologyStem Cell TransplantationTransplant ImmunologyDonor MatchingGraft RejectionGraft-versus-host DiseaseHla MatchingImmunosuppressionTransplant RejectionChronic Granulomatous DiseaseDonor-recipient PairingDonor-recipient RelationshipGranulomatous ReactionsHla Donor-recipient MatchingPost-transplant CyclophosphamideRecipient MatchingStem Cell Donor Matching
A bone marrow graft was performed in a 3 1/2 year old boy suffering from chronic granulomatous disease. Donor-recipient matching was complete in the ABO, HL-A and M.L.C. systems. The number of injected cells amounted to 5.4 X 10(9) (3.6 X 10(8) cells/kg body weight). The immunosuppression regimen consisted of cyclophosphamide and A.L.S. before the graft, and methotrexate after it. Neither graft versus host reaction, nor secondary infection developed. The take of the graft was monitored by the Gm allotypes. Rejection, however, occurred after 2 months.