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Brief Communication: Zinc Intake, Neoplastic DNA Synthesis, and Chemical Carcinogenesis in Rats and Mice
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1975
Year
PathologyHigh Zinc DietsEpigeneticsTumor BiologyOxidative StressDna SynthesisCancer Cell BiologyChemical CarcinogenesisToxicologyHepatotoxicity3-Methylcholanthrene-induced CarcinogenesisBrief CommunicationRadiation OncologyCancer ResearchHealth SciencesLiver PhysiologyExperimental ToxicologyPharmacologyCell BiologyZinc IntakeBioactive MetalMetal ToxicityMetabolismMedicine
DNA synthesis in a transplanted hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene was significantly reduced (P less than 0.01) in rats maintained on diets low (0.4 mug/g) or high (greater than or equal to 500 mug/g) in zinc when compared with control animals given 60 mug zinc/g. 3-Methylcholanthrene-induced carcinogenesis was considerably lowered in mice receiving the same low or high zinc diets during the induction periods.