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Nitrosoureas: useful agents for the treatment of advanced gastrointestinal cancer.
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1976
Year
Advanced Gastrointestinal CancerInduction AgentGastrointestinal OncologyGastrointestinal PharmacologyMedicinePharmacologyGastroenterologyPathologyColorectal CancerGastric CarcinomaGastric CancerAnti-cancer AgentCancer TreatmentOncologyRadiation OncologyCancer Research
Patients with a wide range of gastrointestinal cancers have been treated with nitrosoureas by the Eastern Cooperative Oncology Group. Methyl-CCNU, CCNU, and streptozotocin have been evaluated as single agents in the treatment of colorectal carcinoma. Methyl-CCNU has had an extensive trial in gastric carcinoma as a single agent and in combination with 5-fluorouracil (5-FU). It has also been used to treat pancreatic carcinoma and, in a few patients, carcinoma of the biliary tract. In gastric cancer it would appear that a synergistic effect on response rates has resulted from the combination of methyl-CCNU and 5-FU. The addition of cyclophosphamide to this combination as an induction agent detracted significantly.