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Leflunomide (HWA 486) and its analog suppress T- and B-cell proliferation in vitro, acute rejection, ongoing rejection, and antidonor antibody synthesis in mouse, rat, and cynomolgus monkey transplant recipients as well as arterial intimal thickening after balloon catheter injury.
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1995
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Translational MedicineCell TherapyTransplantationMedicineImmunosuppressive TherapyHematologyImmunologyExperimental TherapeuticAcute RejectionVascular BiologyPharmacotherapyBalloon Catheter InjuryImmunotherapyPharmacologyCell TransplantationGraft RejectionHwa 486
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