A new type of preparative electrophoresis cell

Abstract

action of amidine derivatives in vitro, the diamidines being more active than the monoamidines. Many of the diamidines studied in this paper cause an increase in the blood histamine concentration (MacIntosh & Paton, 1949), due to the release of histamine from the tissues. Some of the compounds which were particularly active as inhibitors of histaminase in our experiments were also highly active in MacIntosh & Paton's experiments. There is no general parallelism between antihistaminase activity and histamine release, but in view of the observations here reported the possibility must be considered that some of these substances exert an antihistaminase effect also in the living animal. SUMMARY 1. The inhibitory action of amidine derivatives on the histaminase of pig kidney has been studied.