Recombinant interleukin-1 receptor antagonist (IL-1ra): effective therapy against gram-negative sepsis in rats. - Concepedia

Concepedia

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Recombinant interleukin-1 receptor antagonist (IL-1ra): effective therapy against gram-negative sepsis in rats.

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References

1992

Year

H. Richard Alexander, Gerard M. Doherty, D Venzon, Maria J. Merino, Douglas L. Fraker, J A Norton

Abstract

IL-1ra lessens the acute hemodynamic, hypothermic, and mortal effects of gram-negative sepsis induced by CLP in rats. These data suggest that IL-1 receptor blockade may be an important new treatment strategy against overwhelming bacterial sepsis.