PubMed · 1992 · 44 citations · 0 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyNeurologic PharmacotherapyNeurorehabilitationNeurocritical Care In TraumaNeurocritical Care PharmacotherapyRecovery CriteriaTraumatic Brain InjuryAcute Traumatic Brain Injury ManagementHead Injury ManagementNimodipine TherapyNimodipine TreatmentRandomized Controlled Trial AppraisalTraumatic Brain Injury Pharmacotherapy
We studied the efficacy of nimodipine in severely head-injured patients in a randomized study. Of 176 patients who received nimodipine, 2 mg/h iv for 2 day, 53% had a favorable outcome (moderate or good recovery). Of 175 control patients, 49% had a favorable outcome. This difference was not statistically significant but does not exclude the possibility that a study of a larger number of patients could show a clinically useful benefit.