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A randomized trial of nimodipine in severe head injury: HIT I. British/Finnish Co-operative Head Injury Trial Group.
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1992
Year
Traumatic Brain InjuryPsychotropic MedicationPharmacotherapyInjury PreventionSevere Head InjuryBrain Injury RehabilitationClinical InjuryStrokeIntracranial PressureBrain InjuryNeurologyRandomized TrialNeurorehabilitationHealth SciencesNeurologic Intensive CareRehabilitationHead-injured PatientsRandomized StudyPatient SafetyControl PatientsMedicineAnesthesiology
We studied the efficacy of nimodipine in severely head-injured patients in a randomized study. Of 176 patients who received nimodipine, 2 mg/h iv for 2 day, 53% had a favorable outcome (moderate or good recovery). Of 175 control patients, 49% had a favorable outcome. This difference was not statistically significant but does not exclude the possibility that a study of a larger number of patients could show a clinically useful benefit.