Life SciencesGeneticsMolecular GeneticsCancer GeneticsGenomicsMolecular OncologyCancer GenomicsDna Damage-induced ApoptosisGenetic HeterogeneityGenomic VariationMolecular CytogeneticsP53 MutationTp53 MutationsTumor Suppressor P53
This report describes a restriction fragment length polymorphism for the enzyme BglII caused by a conserved C to T change at residue 21 of the human p53 gene. This RFLP could potentially be misinterpreted as a rearrangement or a point mutation if paired constitutional tissue is not simultaneously analyzed.