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Nethalide, a beta adrenergic blocking agent
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1964
Year
HypertensionNeuropeptidesCardiovascular PharmacologyPharmacotherapyBlood PressureNeuromuscular BlockadeCardiologyHealth SciencesBlood Pressure MonitoringHeart RateAntihypertensive TherapyPharmacological AgentPharmacologyTen PatientsCardiovascular DiseasePhysiologyExercise PhysiologyBlood Pressure ControlCardiovascular PharmacodynamicsMedicineDrug DiscoveryAnesthesiologyBeta Adrenergic
In ten patients with arterial hypertension and 8 with no cardiovascular disease, the influence on the circulation of a peroral administration of Nethalide, a beta adrenergic blocking agent, was studied. Heart rate, intra‐arterial blood pressure, cardiac output, and oxygen consumption were determined with the subject at rest and during standardized exercise on a bicycle ergometer before and after about one week's treatment. Nethalide did not produce any changes in normal subjects at rest. In the hypeltensive patients, heart rate, brachial arterial pressure, cardiac output, and left ventricular work were lower during treatment than before. Heart rate, brachial arterial pressures, and left ventricular work were lower after tmatment in both groups. In the patients with arterial hypertension, the stroke volume was higher and the peripheral resistance lower after treatment with Nethalide.