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The synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) exerts antiproliferative and apoptosis-inducing effects in the androgen-independent human prostatic JCA-1 cells.
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1995
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ApoptosisImmunologyCell DeathSynthetic Retinoid N-Cell ProliferationCancer-associated VirusAnti-cancer AgentCancer ResearchSignificant ReductionProstatic DiseasePharmacologyCell BiologyTumor MicroenvironmentJca-1 Cell ProliferationEndocrine-related CancerApoptosis-inducing EffectsProlonged ExposureTumor SuppressorMedicine
A significant reduction in JCA-1 cell proliferation was observed as a result of treatment with 4-HPR. This was accompanied by the down-regulated expression of the proliferating cell nuclear antigen PCNA, cyclins D and E, and p34cdc2. Unexpectedly, p53 and pRB was also suppressed in response to 4-HPR. A prolonged exposure to 4-HPR (6 days) promoted the appearance of non-adherent cells showing morphological features and DNA fragmentation patterns indicative of apoptosis.