A series of 250 patients underwent aspiration curettage; 206 of the 250 underwent the procedure in the office without anesthesia. Patient acceptance of the method was good. Hysterectomy or follow-up dilatation and curettage within 24 hours in 97 patients revealed that the diagnosis was correct in 91% of the cases. The method provides an excellent endometrial specimen for histologic examination, has little risk for the patient, and saves considerable time and cost.