Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate

Abstract

The actions of Mitomycin C and Clobetasol were equivalent and not interfere in fibroplasias and in angiogenesis. Both drugs initially cause a decrease in collagen over a 30-day period and an increase over a 60-day period, demonstrating a delay in the wound healing.