Apoptosis-related gene expression affected by a GnRH analogue without induction of programmed cell death in LNCaP cells.

Abstract

In spite of gene modulation, apoptosis was not observed under LA treatment, in agreement with the lack of a cell growth effect when the analogue was used alone. Nevertheless, the observed changes in gene expression may be directly or indirectly involved in the antiproliferative effect of LA on androgen-stimulated cells.