Histological findings of esophageal injury induced by intracavitary irradiation.

Abstract

The histological findings of esophageal injury induced by intracavitary irradiation are reported. In the portion irradiated intracavitarily, denudation and regeneration were found in the epithelium, degenerative changes of small vessels and fibrotic changes were found in the submucosa, and fibrotic changes were also found in the muscle layers. Our data suggest that these characteristic changes correlate with the additional dosage given by intracavitary irradiation following external irradiation.