PubMed · 1982 · 15 citations · 0 references
MedicineCardiologyPharmacologyCardiovascular PharmacotherapyChromatographic AnalysisClinical PharmacologyAffinity ChromatographyChromatographyFamilial HypercholesterolemiaLipid DisordersLipid-lowering TherapyLipoprotein AnalysisHeterozygous Familial HypercholesterolemiaHigh-density Lipoprotein Cholesterol ManagementHomozygous Familial HypercholesterolemiaLdl Cholesterol LoweringLow-density Lipoprotein Cholesterol LoweringLow-density Lipoprotein Cholesterol MeasurementLow-density Lipoprotein Cholesterol ReductionPlasma Cholesterol Levels
Two familial hypercholesterolemic heterozygote patients were treated for a period of 2 years using an extracorporeal technique involving batch affinity chromatography. In both cases LDL-cholesterol levels were drastically lowered and HDL-cholesterol levels were normalized. No untoward side effects were noted during the 2 year experimental period. These results confirm the safety and simplicity of this technique to lower considerably LDL-cholesterol levels in whole blood of familial hypercholesterolemic patients who do not adequately respond to conventional medical treatment.