PubMed · 1988 · 12 citations · 0 references
MedicineNephrologyPathologyAutoimmunityRenal PathologyRenal PharmacotherapyGlomerular DiseasesGlomerular PathophysiologyImmune-mediated Renal DiseaseNephrotic SyndromeRenal DiseaseSystemic Lupus ErythematosusHistologic ExaminationLupus Nephritis TherapyMembranous Nephropathy TherapyNephrotic Syndrome Protein LossNephrotic Syndrome TreatmentProstaglandin ModulationProstaglandin PharmacologyProteinuria Reduction
Prostaglandin E1 was intravenously injected daily for 4 weeks to three patients with lupus nephritis accompanied by severe nephrotic syndrome. Histologic examination revealed diffuse proliferative or membranous glomerulonephritis. Proteinuria decreased markedly 1 year after the treatment with improvement in hypoproteinemia in all three patients. Five years later, the conditions of three cases ameliorated further.